New protocols
The following are protocols open for enrollment by the transplant team at Children's:
- Adoptive immunotherapy for children who relapse with high risk neuroblastoma or other malignancies. This protocol examines the concept of a "mini transplant." This exciting protocol uses therapy that ablates the immune system but is not toxic to the marrow. This study assesses the value of allogeneic stem cell transplantation in a very high risk group to determine the role of graft vs. tumor effect.
- Tandem autologous stem cell rescues for children with recurrent solid tumors. This protocol incorporates the use of double sequential high dose therapy regimens to treat patients who achieve a second complete remission or a partial response. Patients determined to have chemosensitive disease are eligible.
- Tandem autologous stem cell rescues for children with primary or recurrent brain tumors. This protocol utilizes the two most common ablative regimens for brain tumors (CCG, POG) and are given in tandem to patients with high risk brain tumors demonstrating response to chemotherapy.
- Reduced intensity conditioning protocol for related and unrelated hematopoietic stem cell transplantation. This approach can minimize the acute and chronic toxicities of transplantation.