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Liver transplant program

New liver equals new life for Michael

It's not uncommon for parents-to-be to wonder how their unborn child's life will unfold. Will he grow up to be president? Will she be the one to find a cure for cancer? Will he play football with the Bears or basketball with the Bulls? Typical questions, you might say. Every now and then, however, a curve ball is tossed straight out of left field and into your life. Shaking your head, you wonder, "What just happened and why?"

In 1997, Children's Memorial formed a comprehensive transplantation program and recruited a world-class pediatric liver transplantation team.

New parents Anthony and Lisa asked themselves that same question about eight months ago when their 7-week-old son, Michael, was diagnosed with biliary atresia, a fatal disease that blocks the function of the bile ducts.

"This was the last thing we ever expected," says Lisa. "As parents, we have hopes and dreams for our children, and we want to see as few complications as possible. But when something unexpected like this happens, you need to reevaluate your expectations."

Anthony and Lisa's emotional roller coaster ride began in August when Michael's pediatrician noticed he was jaundiced at 6 weeks of age; Michael immediately was sent to Children's Memorial Hospital. At first, Anthony and Lisa didn't know how serious the situation really was. Then, after waiting on pins and needles for six days for the blood and liver biopsy results to come in, the young parents received the news — Michael had biliary atresia. Estella Alonso, MD , hepatologist and gastroenterologist, and medical director of the liver transplantation program , was called in for the case. Dr. Alonso is considered to be one of the country's leading experts in liver failure in children.

Undeniably, there is never a good time to get sick, but being at the right place at the right time may have proven to be a blessing for Anthony, Lisa and Michael. In 1997, Children's Memorial formed a comprehensive transplantation program and recruited a world-class pediatric liver transplantation team. The team is led by Peter F. Whitington, MD , an international expert in pediatric liver disease and transplantation. His colleagues include liver transplantation surgeon Riccardo Superina, MD , surgical director of the liver transplantation program, and Dr. Alonso.

One of Michael's first surgeries included attaching a length of his intestine to his bile duct (this helps drain the bile from the liver). The outlook was favorable for about two weeks, but then Michael's condition started to deteriorate. He went back into surgery for minor adjustments, only to end up with the same results. "Even before his first surgery," says Lisa, "we knew that this would only be a temporary solution for the disease." Eventually, Michael would need a liver transplant.

Meanwhile, the clock was still running. Michael, fortunately, was in relatively good health, but his doctors were concerned that his condition would worsen if they waited any longer. Generally, a healthy child is a better candidate for transplantation rather than one whose health is failing.

A liver transplantation, of course, meant asking another question: where do you get a liver? It's estimated that about 53,000 people are on waiting lists for transplants; almost 4,000 people died last year while waiting for an organ.

"We talked to several other parents at the hospital who were in the same predicament we were. After hearing about the advantages of living-donor transplants versus cadaver liver transplants, we decided that's what we needed to do," Anthony says. Today, living-donor transplants are commonly done, and their success rate is more than 90 percent.

The couple then sat down with Dr. Alonso, who encourages living-donor transplants, and discussed the intricate details of what lay before them. "While the surgery itself poses a minimal risk to the donor, it offers an important psychological edge to parents who feel helpless while waiting for a cadaver organ to become available," says Dr. Alonso. "It's a way of taking control when everything seems chaotic."

Early on, Lisa was ruled out as a potential donor because she had certain health problems, so Anthony underwent testing to see if he would be a viable match as a donor. "I was amazed things went so quickly after that," Anthony says. "I thought we had a few more weeks for testing… until I found out that I had a date with the operating room the following Monday. I guess you could say I was surprised." Anthony was checked out from head to toe — he had a variety of blood tests, a CT scan, EKG, angiogram and psychiatric interview. "It was the most comprehensive physical anyone could ever have," jokes Anthony.

But what came afterward was far from a laughing matter. Three days before Thanksgiving, surgeons at Northwestern Memorial Hospital removed a portion of Anthony's liver, which would later that day be transplanted into Michael at Children's Memorial. Meanwhile, Lisa and her family and friends waited anxiously. Playing the waiting game was just part of the experience, she says. Up until that point, the hospital had been a home to them 35 of 90 days. They even spent time at the nearby Ronald McDonald House after the transplant.

Both operations were a success, and within 72 hours Anthony joined his wife, son and family.

Although Michael is a happy, healthy little boy, he's not entirely out of the woods yet. "He looks great, and his blood counts are wonderful," says Mounif El-Youssef, MD, attending physician in the division of gastroenterology and actively involved in Michael's care, "but it'll be a few more months before we know for sure if his tiny body will accept or reject the new organ."

Looking at the 32-year-old father today holding the tiny, smiling child, it's hard to imagine that just a few months earlier his life — and his son's —rested in the hand of others. "We're very fortunate that Children's Memorial has such a top-notch transplant team," says Anthony. "The physicians, nurses and other hospital staff members have taken their time to help us better understand Michael's condition. And for their expertise and patience, we'll be forever grateful."

Children's Memorial Hospital seeks philanthropic funding to enhance its programs and services. As a proud partner of the Children's Miracle Network (CMN), all funds raised in the Chicago area through CMN also benefit Children's Memorial. To find out how your support can help the hospital better serve children and families, please contact the Children's Memorial Foundation at 773.880.4237 or Foundation@childrensmemorial.org.



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