Research

Craig B. Langman, MD, is the division chief and has a long-standing interest in genetic bone and kidney stone disease. His current work focuses on the translational aspects of genetic bases of these diseases, and pharmacogenetics of specific bone dysplasias.

Richard A. Cohn, MD, is currently the principal investigator for the North American Pediatric Renal Transplant Cooperative Study as well as the medical director of the kidney transplant program at Children's Memorial Hospital. His additional interests lie in childhood nephrotic syndrome and chronic renal insufficiency.

Robert W. Freel, PhD, is an electrophysiologist whose major interest lies in the characterization and regulation of membrane transport processes.

Marguerite Hatch, PhD, has a long-standing research interest in calcium oxalate kidney stone disease. Her research focuses on the mechanisms and control of electrolyte and solute transport across epithelial membranes and includes angiotensin II regulation of ion transport.

Tamoko Hayashida, MD, is investigating the role of SMAD pathway in diabetic nephropathy. Her focus lies in determining the mechanism of "cross-talk" between the ERK and SMAD pathways and the role of TGF-ß1 signaling in human mesangial cell extracellular matrix production.

Jerome C. Lane, MD, has major areas of clinical interest including athogenesis of hemolytic-uremic syndrome (HUS), and mechanisms of clinical progression in congenital renal disease and urogenital malformations. In addition, Dr. Lane has a considerable background and laboratory experience in renal transport of major ions.

Anne-Christine Poncelet, PhD, has a primary research interest in determining the cellular mechanisms by which TGF-ß1 stimulates matrix accumulation in human mesangial cells.

H. William Schnaper, MD, has a substantial basic science interest that is focused on how estrogen modulates endothelial cell signal transduction in blood vessel formation and atherosclerosis, and how mesangial cell responses to growth factors lead to scarring of the filters in the kidney.