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Infectious diseases

Research provides hope for children with HIV

Research provides hope for children with HIV

Dr. Ram Yogev says Children’s Memorial’s 20-year history of participating in clinical trials make it possible for patients to receive the latest HIV medications before they reach the market.

A photo collage featuring the smiling faces of some of his patients hangs on the wall in the office of Ram Yogev, MD. The children vary in age, gender and ethnicity. Yet, they have one thing in common: all have died from AIDS .

If Yogev had his way, research efforts on new therapies underway at Children's Memorial would ensure that no new photos would ever be added to this collection.

“Research makes a tremendous difference in what we can do for children living with HIV,” says Yogev, who is the director of Children's Memorial Research Center's experimental therapeutics programand Center for HIV/AIDS Research. “With clinical trials, we can give kids new medications long before they enter the market, which can make
a real difference in their long-term outcomes.”

Not all pediatric medical institutions offer the advantages of Children's Memorial's 20-year history of participating in clinical trials for children affected by HIV. At any given time 10 to 20 studies of new medications and therapies are available to children in the program. Almost 75 percent are enrolled in government-sponsored trials, and Children's Memorial also participates in a number of pharmaceutical company-sponsored research studies.

Researchers like Yogev and Ellen G. Chadwick are on the cutting edge of discovering new treatments. One new study is following HIV-positive girls who have been immunized against HPV (human papillomavirus), a virus that can cause cervical cancer. If these girls contract HPV they may also be at risk for complications due to their weakened immune systems. In another study led by Yogev, early findings indicate that some children who are vaccinated with their own HIV virus may be able to go as long as six weeks between doses of medication.

While fewer babies are being born with HIV because of advances in perinatal care, the incidence of adolescents contracting the virus is on the rise. A recently announced public-private partnership opportunity to benefit at-risk teens demonstrates Children's Memorial's continuing commitment to finding new ways to address this serious public health challenge, whether through research, clinical care or advocacy .

Children's Memorial Hospital seeks philanthropic funding to enhance its programs and services. As a proud partner of the Children's Miracle Network (CMN), all funds raised in the Chicago area through CMN also benefit Children's Memorial. To find out how your support can help the hospital better serve children and families, please contact the Children's Memorial Foundation at 773.880.4237 or Foundation@childrensmemorial.org.