Lauren M. Pachman, MD
- Professor of Pediatrics, Northwestern University Feinberg School of Medicine
- Director, Disease Pathogenesis Core, Children's Memorial Research Center
- Co-Director, Biomedical Research Component, Northwestern University Multipurpose Arthritis and Musculoskeletal Diseases Center
- Attending Physician, Rheumatology, Children's Memorial Hospital
Contact Information:
Certification
- American Board of Pediatrics
- American Board of Allergy & Clinical Immunology
- American Board of Pediatrics - Sub-Board Pediatric Rheumatology
Education
- BA, Wellesley College
- MD, University of Chicago Medical School
Residency/Fellowship
- Rotating Internship: Philadelphia General Hospital
- Pediatric Residency: Columbia-Presbyterian's Babies Hospital
- NIH post-doctoral fellowship in Immunology: Rockefeller University undefined
Honors
- NIH postdoctoral fellow, 1964–1966
- University of Chicago Medical Alumnae Distinguished Service Award, 1989
- Listed in "America Best Doctors," American Health, 1996 - 2011
- Erwin Neter Memorial Lecture Award: American Med Lab Immunologists, 1996
- University of Chicago Alumnae, Professional Achievement Award, 2001
- Master of Rheumatology, American College of Rheumatology, 2002
- Am Bd Pediatrics, Ped Rheumatol: Award of Distinction, 2003
Professional Organizations
- American Association of Immunologists
- Society of Pediatric Research
- American Pediatric Society
- American College of Rheumatology
- American Association for the Advancement of Science
- Academy of Pediatrics
- Clinical Immunology Society
- The Myositis Association
Offices and Boards
- Midwest Society for Pediatric Research: Past President
- Chicago Rheumatism Society: Past President
- Pediatric Rheumatology Subsection, American Rheumatism Association: Past President
- National Arthritis Foundation:
- Blue Ribbon Research Panel (1996)
- Committee on Education and Patient Services (1994-1996)
- Chicago Association of Immunologists: President 1997-1999
- Clinical Immunology Society: Education Committee—current; Laboratory Council: current
- Board of Directors, Greater Illinois Chapter Arthritis Foundation, 1998-2004
Interests
Dr. Pachman's clinical and research interests center on the regulation of the immune response, both in children with vascular involvement and rheumatic disease, as well as those with primary immunodeficiency disease. Her specific focus is the study of factors affecting the onset and course of the most common pediatric inflammatory myopathy, juvenile dermatomyositis. This focus is implemented by both a national NIH funded study of the epidemiology of JDM (JDM - New Onset Juvenile Dermatomyositis Research Registry) and a NIAMS sponsored laboratory based investigation of genetic and immunological factors that may be associated with a short vs. a long disease course. The course of the disease is altered by therapy; prednisone and other steroids are the primary drugs now used to treat pediatric vascular inflammation. Another study reviews data provided by children admitted to the Clinical Research Center (no patient charges for study) concerning the way that vascular inflammation alters the absorption and metabolism of prednisone when the drug is given by mouth as compared to intravenous administration. In addition, other new biological agents are under investigation for their effect on JDM and other pediatric rheumatic disease. Further information concerning JDM can be obtained from the JDM web pages.
Most Recent Publications
(Selected from 143)
- Smith RL, Sundberg J, Shamiyah E, Dyer A, Pachman LM. Skin Involvement in Juvenile Dermatomyositis (JDM) is Associated with Loss of End Row Nailfold Capillary (NFC) Loops. J Rheumatol, 31:1644-1649, 2004. PMID: 15290747.
- Pachman LM, Lipton R, Ramsey-Goldman R, Shamiyeh E, Abbott K, Mendez EP, Dyer A, Mc Curdy D, Vogler L, Reed A, Cawkwell G, Zemel L, Sandborg C, Rivas-Chacon R, Hom C, Ilowite N, Gedalia A, Gitlin J, Borzy M. History of infection before the onset of Juvenile Dermatomyositis (JDM): results from the National Institute of Arthritis Muscle and Skin Diseases (NIAMS) Research Registry.Arthritis Rheum 53: 166-172, 2005. PMID: 15818654
- Pachman LM , Veis A, Stock A, Abbott K, Vicari F, Byrd R, Giczewski D, Webb C, Spevak L, Boskey AL. Composition of Calcifications in Children with Juvenile Dermatomyositis with Chronic Cutaneous Inflammation. Arthritis Rheum 54: 3345-3350, 2006. PMID: 17009308.
- Rouster-Stevens KA, Pachman LM. Autoantibody to signal recognition particle in African-American girls. J Rheumatol 35:927-929, 2008. PMID: 18322984.
- Niewold TB, Kariuki SN, Morgan GA, Shrestha S, Pachman LM. Elevated serum interferon-alpha activity in juvenile dermatomyositis: Associations with disease activity at diagnosis and after thirty-six months of therapy. Arthritis Rheum. 2009 Jun;60(6):1815-24. PMID: 19479879
- Niewold TB, Kariuki SN, Morgan, GA, Shrestha S, Pachman LM. Gene-Gene-Sex Interaction between Cytokine Gene Polymorphisms Revealed by Serum IFN-α Phenotype in Juvenile Dermatomyositis. J Pediatr. 2010 Oct:157(4):653-57 PMID: 20605164
- Niewold T, Wu S, Smith M, Morgan G, Pachman LM. Familial Aggregation of Autoimmune Disease in Juvenile Dermatomyositis. Pediatrics. 2011 May;127(5):e1239-46. PMID:21502224
Recent Chapters/Invited Publications
- Pachman LM : Polymyositis and dermatomyositis in children. In The Oxford Textbook of Rheumatology. (ed.) Maddison PJ, Isenberg DA, Woo P, Glass DN, Oxford University Press, Oxford; pp.914-921, 2004.
- Pachman LM. Juvenile Dermatomyositis, In: Nelson Textbook of Pediatrics, 18th edition (Ed) RM Kliegman,) RE Behrman, HB Jenson, BF Stanton. Elsevier Saunders, Philadelphia PA pp 1019-1024, 2007.
- Feldman BM, Reed AM, Rider LG, Pachman LM. Juvenile dermatomyositis & other idiopathic inflammatory myopathies of childhood. Lancet 371:2201-2212, 2008.
- Pachman LM. Juvenile Dermatomyositis: An Update on Clinical and Laboratory Findings, pp.55-87 In The Inflammatory Myopathies, (Ed) Kagen LJ, Humana Press, a part of Springer Science+Business Media, New York, 2009. Pages 55-86.