Research
The physicians of the Division of Dermatology are dedicated to performing clinical and basic science research in areas of interest within the field of pediatric dermatology. They also participate in the education of medical students, pediatric and dermatology residents, pediatric dermatology fellows and practicing pediatricians and family practitioners.
Clinical research includes our participation in clinical trials of newer medical treatments for atopic dermatitis, psoriasis, acne, hair loss disorders, and epidermolysis bullosa, as well as collaboration with other divisions in the medical center on a multitude of projects applicable to pediatric dermatologic practice.
The Division of Dermatology's research laboratory, run by Amy Paller, MD, is pursuing NIH-funded research to explore the role of gangliosides in the function of skin cells (keratinocytes). Gangliosides are components of the cell membrane that are made of carbohydrates and lipids.
Dr. Paller's laboratory continues to perform pioneering bench research that has shown that the gangliosides interact with several important cell receptors, including the epidermal growth factor receptor and integrin alpha5beta1, to affect how skin cells grow, attach, and move.
Her laboratory has introduced genes that alter the content of membrane gangliosides and cells in culture to make these discoveries. These findings are likely to have an impact on patients with psoriasis, poor wound healing, and skin cancers.
Sarah L. Chamlin, MD, and quality of life measurements
To measure the effects of atopic dermatitis on the quality of life of young children (under the age of 6 years) and their families, Sarah Chamlin, MD, and colleagues have developed a survey known as the Childhood Atopic Dermatitis Impact Scale (CADIS). The CADIS was developed based on input from parents and expert clinicians. The survey tool examines children's symptoms, activities and behavior as well as parent's issues such as family/social functions, sleep, and emotions. More about the survey tool here.
Clinical outcomes and quality of life research as they pertain to atopic dermatitis and blood vessel tumors (hemangiomas) are also areas of special interest for Dr. Chamlin.
Our entire faculty is active at the national and international level in delivering medical lectures and advocating for patients with pediatric dermatological diseases.